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 November 2002 (v02-n11)
Main Story - pgs. 1-14 ZymoGenetics
Macro Market Commentary - pgs. 15
Recommended Readings - pg. 16
NIBM Model Portfolio Updates - pg. 17-21
NIBM Model Portfolio - pg. 22
(Full outline below...)

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This month's Main Story is a brief exploration of ZymoGenetics (NASDAQ:ZGEN). Zymo is one of the country's oldest biotechnology companies. Their R&D team is responsible for products with annual sales of nearly $3 billion, but they've only been public for about a year and their market cap is less than $400 million. To understand this disconnect, learn the science behind their products, and discover their promising pipeline, read this edition of our newsletter.

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The following is an outline of this issue of the NIBM Newsletter.

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Main Story - ZymoGenetics
Introduction
Table: Basic Facts
Disclosures
Investment thesis
Writing and research credits
 
Novo Nordisk Detour
Table: Zymo-developed Novo Nordisk products
Novo royalties
Table: Other Zymo-developed products on the market
Novo's hold on the pipeline
 
Protein Science
The basics
What is a protein?
The patent race
The valuation problem
 
Products
Table: Zymo products
Recombinant Factor XIII
        Blood coagulation
        The drug
        Clinical trials
        Table: rhF13 uses
        F13 in inflammatory bowel disease
        F13 in Graft versus Host Disease
       Sales and manufacturing
Recombinant human thrombin
TACI-ig
       The science
       Diseases
       The drug
       Partner
       Competition
IL-21

Management and Operations

What Can Go Wrong

Macro Market Commentary

Recommended Readings

NIBM Model Portfolio and Updates
Dendreon
Genta
Indevus
Seattle Genetics
Indevus
ID Biomedical
Nabi
AltaRex
Targeted Genetics
 
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