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 January 2003 (v03-n01)
Main Story - pgs. 1-16 AVANT Immunotherapeutics
Macro Market Commentary - pgs. 17-18
Biotech Monthly Coverage Update - pg. 19-22
NIBM Model Portfolio - pg. 23
(Full outline below...)

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This month's Main Story explores vaccine maker AVANT Immunotherapeutics. The company specializes in making vaccines for bacterial and viral diseases. The vaccines are typically administered in a single dose by drinking a small amount of liquid.

The company is also pursuing an anti-cholesterol vaccine aimed at the controversial CETP target.

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The following is an outline of this issue of the NIBM Newsletter.

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Main Story - AVANT Immunotherapeutics
Introduction
Table: Basic Facts
Disclosures
Investment thesis
 
CETi-1
CETP and Cholesterol
The race for HDL efficacy
Reverse lipid transport and HDL science
Atherosclerosis
Table: Major particle players
Reverse Lipid Transport (RLT)
The CETP controversy
CETi-1 clinical history
Phase Ia
Phase Ib
Phase II
Competition
Pfizer's CP-529,414
Japan Tobacco's JTT-705
Competitive picture
Why care about CETi-1
 
89-12/Rotarix
Rotarix in the clinic
Follow-up
Table: Rotarix Phase II results (includes 2-yr follow-up data)
RotaShield
Rotarix clinical path
 
Peru-15/Cholera-Garde
Clinical experience
 
Ty-800
 
Other products
Traveler's Vaccine line
Military
Anthrax
Complement Inhibitors
Therapore
Food safety
 
Finances and Operations
Table: AVANT Milestones

What Can Go Wrong

Macro Market Commentary

Biotech Monthly Coverage Updates
Nabi
Dendreon
PAREXEL
Esperion
Table: Timeline updates
AltaRex
ID Biomedical
Alteon
Onyx Pharmaceuticals
Alliance Pharmaceuticals
 
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