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 August 2003 (v03-n08)
Main Story - pgs. 1-14 Introgen Therapeutics
Macro Market Commentary - pgs. 15-16
Biotech Monthly Coverage Update - pg. 16-24
NIBM Model Portfolio - pg. 25
(Full outline below...)

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Introgen Therapeutics (NASDAQ:INGN) is an Austin, Texas biotechnology company developing gene-based therapeutics for treating cancer. The company is focused on developing gene therapies for the treatment of cancer alone or in combination with other "conventional" treatments.

Introgen was the first company to initiate clinical testing with an in vivo (direct administration to the patient) gene drug in 1995. Introgen’s lead product, Advexin, is in pivotal trials for treating head and neck cancer, and is headed towards pivotal trials for non-small cell lung cancer. Advexin uses an adenovirus to delivery a complete copy of the p53 gene to cells. When delivered to tumor cells, the complete p53 gene is thought to be instrumental in helping them die.

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The following is an outline of this issue of the NIBM Newsletter.

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Main Story - Longevity earns Introgen another look
Introduction
Table: Basic facts on Introgen
Disclosures
Investment case
Financial and other information
The Opportunity
Gene therapy basics
The vector
The adenovirus vector
 
Products
Table: Introgen's products
Table: Introgen's product development programs
Sidebar: New cancer treatments & apoptosis
Advexin
Clinical trials
Table: Advexin Phase II clinical trials
Is it gene therapy?
Data shared after approval
INGN 241
INGN 225
Other drug candidates
Collaborative relationships

Table: Introgen selected milestones

What can go Wrong

Macro Market Commentary - "Welcome to our bunker"

Biotech Monthly Coverage Updates
Indevus
Sonus
Genta
Nabi
Dendreon
Targeted Genetics
PAREXEL
Esperion
AltaRex
ID Biomedical
Table: Challenge trial arms
Discovery Labs
Akorn & Laureate Pharma
ARDS partnership
Aerosolized surfactant partnership
First indications for aerosolized surfactant
Mini-primer on aerosolized surfactants
Alteon

NIBM Model Portfolio Performance

 
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