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 June 2006 (v06-n06)
Main Story - OvaRex window into immunotherapy - pgs. 1-12
Macro Market Commentary - pgs. 13-14
Research Director's Rant - pgs. 15-16
BSR Coverage Update - pgs. 17-35
Biotech Sector Short Interest - pg. 36
BSR Model Portfolio - pgs. 37-38
(Full outline below...)

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June's Biotech Monthly uses United Therapeutics' (UTHR) drug OvaRex as a vehicle to examine recent trends and advancements in cancer immunotherapy. Inspired by a reinvigoration of this field at ASCO 2006, the June issue gives you details on a drug that could be very important for UT and a peek inside the next steps in the search for an effective way to harness the immune system to treat cancer.

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The following is an outline of this issue of Biotech Monthly.
Main Story - OvaRex provides window into future immunotherapy
Introduction

Investment Case

Disclosures

OvaRex redux
Quick note on mechanism
The quirky trial
The optima subset
Too much porridge
Too little porridge
Just right
Final follow up
Table: Median progression-free survival
Table: Median survival
Current study
The New Immunotherapy
Theory
Back to OvaRex
When to administer?
Table: After frontline chemotherapy?
Table: With recurrent disease?
Concurrent with front-line chemotherapy
Next steps
CTLA-4 as the next new thing
T-regs and killer DCs
It's all about balance, Grasshopper
Table: Halting immunosupression
Macro Market Commentary - "Bad timing, so brief comments"

Research Director Rant - "Measuring one CEO"

Biotech Monthly Coverage Updates

Cypress Bioscience
Table: Milnacipran pivotal trials for FS
Obstructive sleep apnea
Investment case
Dendreon
Market size
Manufacturing
The what changed question
Other items
Label
Progression advantage
Label expansion
BLA vs. Launch
P-16 window to P-11
NCI/FDA cancer immunotherapy workshop
9901 publication
Investment case
Forbes Medi-Tech
Investment case
Hana Biosciences
Indevus
Investment case
Introgen
Medarex
Investment case
Neurochem
Table: Basic facts
Table: Neurochem timelines
Investment case
Oncolytics Biotech
Valentis
Targeted Genetics
ZymoGenetics

Biotech Sector Short Interest

BSR Model Portfolio Performance

 
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