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 July 2006 (v06-n07)
Main Story - Dynavax - pgs. 1-19
Macro Market Commentary - pgs. 20-22
BSR Coverage Update - pgs. 23-34
Biotech Sector Short Interest - pg. 35
BSR Model Portfolio - pgs. 36-37
(Full outline below...)

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July's Biotech Monthly debuts BSR's coverage on Dynavax (DVAX), the Berkeley, CA company who we feel is a leader in the toll-like receptor (TLR) field. They have two drugs in Phase III trials. Heplisav is a preventative vaccine for hepatitis B. Tolamba is a drug for people with ragweed allergies. They also have a budding oncology program, leveraging the unique innate immune system stimulant properties of TLRs.

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TLRs are one of the hottest new technology areas in biotech right now. This issue not only describes why Dynavax interests us, it serves as an update to our previous issues on TLRs.

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The following is an outline of this issue of Biotech Monthly.
Main Story - Dynavax leads the pack
Introduction
Table: Company statistics

Disclosures

Investment case

Financial review
Table: Basic facts for quarter ending June 30, 2006
Guidance for FY-2006
Rhein Biotech acquisition
Table: Key points in favor of acquiring Rhein Biotech
Symphony Dynamo
Table: Symphony Dynamo: What each side gets
Table: Major shareholders
The Science of Dynavax
Why so many TLR companies?
Quick description of Toll-like receptors
Table: Known TLRs and their ligands
TLR drugs in development
Table: TLR drugs
Why TLR9?
Why TLR9 drugs?
TLR9 drug classes
Table: Three class of TLR9 drugs
Patent disputes
Conjugation
Dynavax drug portfolio
Table: Dynavax product pipeline & timelines
HBV program
Table: Products acquired from Rhein Biotech
Tolamba
Cancer
Sidebar: ZymoGenetics and IL-21
What Can Go Wrong
Macro Market Commentary - "May you live in interesting times"

Biotech Monthly Coverage Updates

Corcept
Table: Corcept pivotal trials
Milestones
Hidden gem
Investment case
Cortex
Discovery Labs
Table: Basic facts for quarter ending June 30, 2006
Reducing cash burn
Table: Cash considerations
Manufacturing Update
Investment case
Forbes Medi-Tech
Investment case
Genta
Investment case
Hana Biosciences
Investment case
Indevus
Investment case
Neurochem
Investment case
Oncolytics Biotech
Praecis
YM Biosciences
DEC trial
Table: Sequential analysis stopping rules

Biotech Sector Short Interest

BSR Model Portfolio Performance

 
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